In molecular biology the DHHC domain is a protein domain that acts as an enzyme, which adds a palmitoyl chemical group to proteins in order to anchor them to cell membranes. The DHHC domain was discovered in 1999 and named after a conserved sequence motif found in its protein sequence. Roth and colleagues showed that the yeast Akr1p protein could palmitoylate Yck2p in vitro and inferred that the DHHC domain defined a large family of palmitoyltransferases. In mammals twenty three members of this family have been identified and their substrate specificities investigated. Some members of the family such as ZDHHC3 and ZDHHC7 enhance palmitoylation of proteins such as PSD-95, SNAP-25, GAP43, Gαs. Others such as ZDHHC9 showed specificity only toward the H-Ras protein. However, a recent study questions the involvement of classical enzyme-substrate recognition and specificity in the palmitoylation reaction. Several members of the family have been implicated in human diseases.
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{"fact":"Cats lap liquid from the underside of their tongue, not from the top.","length":69}
{"type":"standard","title":"Goodbye Yellow Brick Road","displaytitle":"Goodbye Yellow Brick Road","namespace":{"id":0,"text":""},"wikibase_item":"Q827363","titles":{"canonical":"Goodbye_Yellow_Brick_Road","normalized":"Goodbye Yellow Brick Road","display":"Goodbye Yellow Brick Road"},"pageid":1203860,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/en/8/86/Elton_John_-_Goodbye_Yellow_Brick_Road.jpg","width":300,"height":300},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/en/8/86/Elton_John_-_Goodbye_Yellow_Brick_Road.jpg","width":300,"height":300},"lang":"en","dir":"ltr","revision":"1293350389","tid":"f8f007fe-3eb4-11f0-a245-e53c475b3759","timestamp":"2025-06-01T06:52:24Z","description":"1973 album by Elton John","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Goodbye_Yellow_Brick_Road","revisions":"https://en.wikipedia.org/wiki/Goodbye_Yellow_Brick_Road?action=history","edit":"https://en.wikipedia.org/wiki/Goodbye_Yellow_Brick_Road?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Goodbye_Yellow_Brick_Road"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Goodbye_Yellow_Brick_Road","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Goodbye_Yellow_Brick_Road","edit":"https://en.m.wikipedia.org/wiki/Goodbye_Yellow_Brick_Road?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Goodbye_Yellow_Brick_Road"}},"extract":"Goodbye Yellow Brick Road is the seventh studio album by English singer, pianist, and composer Elton John. A double album, it was released on 5 October 1973, by DJM Records. Recorded at the Château d'Hérouville in France, the album became a double LP once John and his band became inspired by the locale. Among the 17 tracks, the album contains the hits \"Candle in the Wind\", US number-one single \"Bennie and the Jets\", \"Goodbye Yellow Brick Road\", and \"Saturday Night's Alright for Fighting\", along with the live favourites \"Funeral for a Friend/Love Lies Bleeding\" and \"All the Girls Love Alice\".","extract_html":"
Goodbye Yellow Brick Road is the seventh studio album by English singer, pianist, and composer Elton John. A double album, it was released on 5 October 1973, by DJM Records. Recorded at the Château d'Hérouville in France, the album became a double LP once John and his band became inspired by the locale. Among the 17 tracks, the album contains the hits \"Candle in the Wind\", US number-one single \"Bennie and the Jets\", \"Goodbye Yellow Brick Road\", and \"Saturday Night's Alright for Fighting\", along with the live favourites \"Funeral for a Friend/Love Lies Bleeding\" and \"All the Girls Love Alice\".
"}